System and method for measuring reaction time of a subject

ABSTRACT

There is provided herein a motion-based evaluation of reaction time that utilizes motion detection hardware of a mobile device to determine auditory and visual stimulated reaction time. In an embodiment, the subject holds a mobile computing device equipped with built-in triaxis accelerometer and gyroscope with both hands at arms length away from the face. A visual or auditory stimulus is then presented on screen via a software application that also records the response time for the individual to initiate a movement of the device. A simple reaction time test could include the movement of the device in any direction that exceeded a threshold of movement beyond what would be expected from static holding. An embodiment of a choice reaction time test would provide for specific directional movements as it related to an instructed stimulus.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional PatentApplication Ser. No. 61/885,278 filed on Oct. 1, 2013, and incorporatessaid provisional application by reference into this document as if fullyset out at this point.

FIELD OF THE INVENTION

The present invention relates generally to the field of cognitive andneuropsychological assessment.

BACKGROUND OF THE INVENTION

The development of more portable assessment techniques of cognitive andvestibular characteristics has been well documented by researchers andinnovators. Techniques for assessing subject memory, reasoning,discrimination, intellect, etc., using mobile devices have beendeveloped. However, reaction time has not shown consistent measures. Thehigh variability in mobile device touch-screen based reaction timetesting presents a problem for accurate assessment of reaction time thatis not typically seen with desktop/laptop computer-based approaches thatrecord reaction time with mouse clicks or pressing a key such as thespace bar.

Reaction time is a measure of sensory and neuromotor function thatencompasses stimulus recognition and processing followed by theinitiation of a neuromotor response. Reaction time can be tested withvarying levels of difficulty in the sensory phase, or the neuromotorresponse phase. The Simple Reaction Time (SRT) test is the mostelementary form of reaction time measurement, which looks at signalprocessing of a single stimulus with a defined physical response, suchas pressing a button.

Reaction time is typically evaluated digitally via a computer programrunning on a desktop computer, which measures the time lapse betweenstimulus presentation on the screen and the touch of a keyboard or clickof a mouse. More practical and accessible tools for reaction timeassessment have been suggested, however these tools are typically notdigitally connected for archiving individualized comparativemeasurements and require equipment that is not always available outsideof the clinic.

Computerized testing is generally accepted as the gold standard forreaction time assessment. Inherent in the reaction time measurement is atime lag (latency) between the time a key is depressed and when it isregistered by the computer. Computerized testing remains popular despitemouse and keyboard latency variations of 20 to 50 milliseconds betweencommercially available models. Additionally, a practical limitation ofcomputerized testing is the immobility of the testing platform.

Recent efforts to promote cognitive assessment on mobile devices haveattempted to address the portability issue in computerized testing withthe use of touch screen devices such as cell phones. A transition totouch screen reaction time assessment has been slowed due to latency inthe touch identification mechanisms of mobile devices. Recent studieshave failed to produce statistical equivalence between touch-basedreaction time assessment and computerized testing.

More concerning is the latency caused by delays between the time when auser's finger contacts a touch screen and the time that contact isregistered by the CPU. This can introduce inaccuracies into measuredreaction time values. In some cases, depending on the hardware andsoftware resident within the mobile device, the latency might be between20 and 100 milliseconds (i.e., between about 0.020 and 0.100 seconds).With average human simple reaction time scores of 230 ms, and standarddeviation of 20 ms, the current touch screen latency does not provide amedium for accurate measures. A small sample of neurocognitive testingon a mobile device showed slower and more variable measurements ofresponse times when compared against computerized models. There remainsa critical need for more accurate reaction time measures on touch-screenportable computing devices.

Additionally, user experience inconsistencies in the touching actionwith variability of initial finger distance from the screen createinconsistencies in accurately measuring response time. Distance of thefinger from the screen had a significant effect on reaction time score.Additional use cases have been presented where the user begins withscreen contact and removes the finger as a capture of response tostimulus. This action has an improved accuracy of reaction time score,but still contends with the scanning rate of the run loop and screeninput latency.

In short, the technical translation of touch screen reaction timedetection to this point may fail to accurately measure reaction time inboth simple and choice reaction time trials.

As such there has been, and remains, a critical need for more accuratereaction time measures on touch-screen portable computing devices.

Heretofore, as is well known in the cognitive testing industry, therehas been a need for an invention to address and solve the disadvantagesof prior art methods. Accordingly it should now be recognized, as wasrecognized by the present inventors, that there exists, and has existedfor some time, a very real need for a system and method that wouldaddress and solve the above-described problems.

Before proceeding to a description of the present invention, however, itshould be noted and remembered that the description of the inventionwhich follows, together with the accompanying drawings, should not beconstrued as limiting the invention to the examples (or preferredembodiments) shown and described. This is so because those skilled inthe art to which the invention pertains will be able to devise otherforms of the invention within the ambit of the appended claims.

SUMMARY OF THE INVENTION

According to an embodiment there is provided a motion-based evaluationof reaction time that utilizes the motion detection hardware of a mobiledevice to determine auditory and visual stimulated reaction time.

In one embodiment, the subject will hold a mobile computing deviceequipped with built-in triaxis accelerometer and/or gyroscope with bothhands at arms length away from the face. A visual or auditory stimuluswill then be presented on screen via a software application that recordsthe response time for the individual to initiate a movement of thedevice. In one embodiment the acceleration of the device will becontinuously measured from an onset time until after a substantialmovement is recorded post-presentation of the stimulus. Then, thecontinuously recorded acceleration curve will be searched to determinethe earliest intentional movement in the same axis as the substantialmovement that broke a given threshold after presentation of thestimulus. The time difference between the presentation of the stimulusand the earliest intentional movement will be a measure of reactiontime.

Another embodiment will continuously monitor the gyroscope in thehandheld device from an onset time until after a substantial change inorientation is sensed. As in the previous embodiment, after the changeis sensed the earliest intentional change will be identified and thetime of such change noted. The time difference between the presentationof the stimulus and the time of the first intentional orientation changewill then be used as a measure of reaction time.

As a further example, a simple reaction time test could include themovement of the device in any direction that exceeded a threshold ofmovement beyond what would be expected from static holding. Anembodiment of a choice reaction time test would provide for specificdirectional movements as it related to an instructed stimulus.

The foregoing has outlined in broad terms the more important features ofthe invention disclosed herein so that the detailed description thatfollows may be more clearly understood, and so that the contribution ofthe instant inventors to the art may be better appreciated. The instantinvention is not limited in its application to the details of theconstruction and to the arrangements of the components set forth in thefollowing description or illustrated in the drawings. Rather theinvention is capable of other embodiments and of being practiced andcarried out in various other ways not specifically enumerated herein.Additionally, the disclosure that follows is intended to apply to allalternatives, modifications and equivalents as may be included withinthe spirit and the scope of the invention as defined by the appendedclaims. Further, it should be understood that the phraseology andterminology employed herein are for the purpose of description andshould not be regarded as limiting, unless the specificationspecifically so limits the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

Other objects and advantages of the invention will become apparent uponreading the following detailed description and upon reference to thedrawings in which:

FIG. 1 contains an illustration of a general environment of anembodiment of the invention.

FIG. 2 contains a hardware schematic of an embodiment.

FIG. 3 contains an operating logic suitable for use with an embodiment.

FIG. 4 contains a schematic illustration of a response time curve.

DETAILED DESCRIPTION

The present invention, in one embodiment, is a software applicationrunning on a mobile device that is equipped with an accelerometer and,in some embodiments, a gyroscope. Readings from the device when thenprovide data that measures elements of cognitive function based onmotion response. One software application measures simple and choicereaction time which might be initiated by, for example, presenting theuser with a stimulus such as turning the entire screen to the color red,and timing a response to initiate movement. Another reaction time testpresents the user with arrows that indicate the direction to move thedevice, as well as associative relationships with colors, which presentan added level of cognitive function to recall color association. Aswith any reaction time test, the user is indicated that the stimuluswill be presented and a one to four second fore period precedes theactual presentation of the stimulus.

The present invention, according to one embodiment, is a softwareapplication that runs on a mobile device that measures elements ofcognitive function based on motion response. The motion response isquantified, for example, using an accelerometer and/or gyroscope that isintegral to the mobile device. Simple and choice reaction time can bemeasured by presenting the user with a stimulus such as turning theentire screen to the color red, and timing a response to initiatemovement. An example of a choice reaction time test would present theuser with arrows in the direction to move the device, as well asassociative relationships with colors, which would present an addedlevel of cognitive function to recall color association. As with anyreaction time test, the user will be notified that the stimulus is to bepresented and a one to four second fore period will precede the actualpresentation of the stimulus.

Turning first to FIG. 1, there is provided a method of measuringreaction time by executing a program on a portable computing device suchas a cell phone 100. According to an embodiment, the device 100 willcontain an accelerometer and use motion of the device to assess accessreaction time as discussed below.

FIG. 2 contains a schematic illustration of a hardware configurationthat would be suitable for use with an embodiment 100. In the embodimentof this figure, the portable device 100 will contain an accelerometer210 and/or a gyroscope 240 that are in electronic communication with aCPU 220. Not shown is some amount of memory (volatile and/ornonvolatile) that would be useful in connection with the softwareembodiment of the instant disclosure. Additionally, there will typicallybe provided a device such as a LED or other display device 230 whichcould be used to communicate information to a user. The interconnectionbetween the CPU 220 and the display device 230 is shown to bebidirectional because, in some embodiments, the display device might bea touch-sensitive display and the CPU 220 might be programmed to obtaininformation from the user via the display 230.

Note that one potential use for the display device 230 would be toinitiate a response time test (e.g., by changing color, flashing,printing a “START” or other text message, etc.). That being said thoseof ordinary skill in the art will recognize that a test could beinitiated in any number of other ways including, for example, soundingan audible tone, vibrating the device (e.g., using the vibration mode ofa phone), etc. Although some embodiments will be based on an AppleiPhone® that is not a requirement and any device that that can be handheld or worn on the body (such as a wrist watch or glasses) and thatcontains an accelerometer or gyroscope could potentially be utilized.

The CPU 220 might be within the same enclosure as the accelerometer 210or in electronic communication with it (either wired or wireless).Multiple CPUs might be involved as would be the case where a multicoredevice is used (e.g., where different functions are handled by differentcores), or where separate CPUs that are in electronic communication witheach other.

One function of the CPU 220 is continuously read the accelerometer 210from a time before the start of the test until after a response isidentified or until after a predetermined period of time has passed.Note that for purposes of the instant disclosure when the word“continuously” is used herein, that usage should be understood to meanthat an operation is performed repeatedly during some period of time.For example, if a quantity is said to be continuously measured duringsome time period, that could mean that the quantity is measured everysecond, every 0.1 seconds, every 0.01 seconds, etc., with themeasurements spacings being dependent on the length of the time periodand context in which the term appears. Additionally, it should be notedthat the operations (measurements in the current example) need not beequally spaced throughout the measurement period but only that theyshould be spaced apart. Thus, and by way of example only, in oneembodiment “continuously” will mean nominally performed 500 to 1000times a second, i.e., at intervals of 1 to 2 milliseconds, where theactual spacing between successive measurements might vary about thenominal value. Those of ordinary skill in the art will recognize thatthe sampling interval might be longer or shorter than this and selectingsuch will be will within the ability of one of ordinary skill in theart.

In one embodiment the accelerometer 210 will be a three-component(triaxis) accelerometer. In some embodiments both an accelerometer 210and a gyroscope 240 will be present in the same device.

Turning next to FIG. 3, this figure contains an operating logic suitablefor use with an embodiment. With respect to box 310, as an initial stepthe test subject will be provided with a hand-held device suitable foruse with the methods taught herein and instructed in its use. Moreparticularly, in many embodiments this will be an iPhone® or othercellular telephone on which a computer program that is designed toperform the operations described below in connection with the currentembodiment. Of course, it is not required that a telephone be used. Allthat is required is that the device contains a CPU (to include anyprogrammable device such as microprocessor, micro controller,programmable gate array, etc.) that is in electronic communication witha module that can sense movement and/or orientation of the device.

Note that, in some embodiments, the user might be asked to hold thedevice with as little movement as possible for a period of time toestablish a baseline stability curve. It should be clear that someindividuals will be able to hold the test device relatively motionlesswhereas others, for physical or other reasons, might have moredifficulty doing this. As such, it might be useful to establish abaseline stability (e.g., the average acceleration during thecalibration time) before collecting data. The baseline stability couldthen be used in connection with the determination ofsubstantial/significant movement thresholds discussed hereinafter.

In one embodiment, the test subject will be instructed to hold thedevice in a landscape orientation with both hands on the device as issuggested by the example of FIG. 1 on which software which is designedat least in part to implement an embodiment of the methods taught hereinhas been preloaded. Clearly, if the software has not been preloaded insome variations in might be downloaded to the device via a wireless orwired connection. The user will then be asked to presses “Begin Test”(step 315) or provide some similar indicium to the recording device toindicate that s/he is ready to begin testing. In some embodiments, thiswill signal the beginning of the onset time, the time during which themotion of the device will be recorded.

Next, according to some embodiments the sensor that is responsible fordetermining motion of the device will be continuously read and saved fora period of time to be described below (step 318), where continuouslyshould be understood to take the meaning ascribed to it herein. In someembodiments, the sample interval for such continuous sampling might be 1or 2 milliseconds. In some embodiments, the accelerometer or otherdevice responsive to motion will be read at 1 or 2 millisecond intervalsby the instant invention according to methods well known to those ofordinary skill in the art, each such reading producing at least onevalue representative of motion.

Note that in embodiments that utilize a three-component accelerometer,each reading from such a device might result in three values:acceleration in each of an X, Y, and, Z direction with respect to thedevice. In some embodiment, the three units of motion that might be readfrom such a device will be combined into a single/composite valuerepresentative of the overall motion of the device in some embodiments.In other instances, one or more components of acceleration might beused. For example, in some embodiments only the vertical component ofacceleration might be used. In some embodiments (e.g., where the userhas not held the device in a perfectly horizontal position initially) itmight be necessary to numerically extract the vertical component ofacceleration from the three-component values that are read from theaccelerometer, e.g., if the subject has been asked to move the devicevertically in response to the stimulus. No matter how it is determined,for purposes of example and discussion only it will be assumed that asingle value that is representative of the motion of the device has beenobtained that can be used to indicate motion of the device.

As has been discussed previously, although some embodiments of theinvention utilize a sensor in the form of an accelerometer or gyroscopeto sense motion, it should be understood that these devices have beengiven by way of example only and not of limitation. For example, adigital camera could also function as a motion sensor either, forexample, by using the anti-shake feature of the camera to sense motionor by using the field of view of the camera (e.g., by requiring the userto point the camera at a static image, e.g. a target, and noting thechanges in the camera's field of view). That being said, anaccelerometer or gyroscope would generally provide better results.Additionally, an embodiment uses multiple of the above (e.g., both anaccelerometer and a gyroscope) to sense motion. One motion source couldbe used as a check against the other or the measurements could becombined and utilized as follows.

A randomly selected fore period can be used to prevent anticipation ofthe stimulus (step 320). Although this time interval might be randomlyselected it also could be selected deterministically depending on theneeds of the supervising user. Clearly, the measurements might be calledinto question if there were a pattern in a repeated presentation of astimulus or if the timing were such that it could be accuratelyanticipated.

Next in some embodiments a stimulus will be presented to the user (step325). The stimulus might take many forms. In some embodiments thestimulus will be presented by printing a text message on the screen,changing the color of the screen, flashing the handheld devices cameraflash, etc. In other instances, an audible tone or vibration of thedevice might be utilized as the stimulus.

After the stimulus has been presented, the sensor will be repeatedlyread (330) and retained in memory until either a substantial movement isnoted (step 335) or until the elapsed time exceeds some predeterminedvalue (e.g., 1, 2, 3, 5, 10, etc., seconds, step 340). In someembodiments, a substantial movement will be a movement that exceeds apredetermined threshold. Note that, in some embodiments, rather thanfinding the first single value that exceeds the movement threshold, somenumber of sequential measurements that exceed that value might berequired (e.g., 2, 3, 5 or more, etc.) before a substantial movement isidentified. In the event that the movement sensor is an accelerator, themovement threshold might be the time at which a value greater than orequal to 0.1 g is sensed. Clearly, other thresholds could be chosen bythose of ordinary skill in the art.

One purpose for the timeout is to accommodate those instances where auser abandons the test after indicating a readiness to take it. In thatcase, an error message might be displayed (step 345) and the routineterminated. However, in some embodiments the “YES” branch of decisionitem 340 might branch directly to step 350 instead of ending theroutine. This might be useful if there is a high noise level, if it issuspected that a predetermined ending time would always include thesignificant movement, etc. In that instance, the substantial movementtime could be set equal to the predetermined ending time and the methodcontinued as described below.

If, after the onset of the test, a substantial movement has not beendetected and the timer has not expired, a new value will be read fromthe sensor (step 330). The value that is read will be stored orotherwise retained for subsequent use.

Once the movement exceeds a predetermined threshold (the “YES” branch ofdecision item 335), an embodiment will search through the recordedmotion readings since the onset and find the first time a significantmotion occurs.

Once the time of the earliest significant movement is determined, theresponse time can be calculated as the elapsed time since thepresentation of the stimulus (“T1” in FIG. 4). FIG. 4 contains aschematic representation of how a motion response curve might appear.Typically, the response time will be immediately communicated to thetest administrator (e.g., via WiFi or Bluetooth) and/or accumulated andreported at the end of the testing procedure (e.g., when the device ishanded back to the administrator). The individual curves themselvesmight be communicated to the test administrator or not depending on thepreferences of the software designer and/or the test administrator.

Finally, in some embodiments one or more additional tests will beperformed (the “YES” branch of decision item 360). As a specificexample, in some embodiments each user will be asked to perform fivetests which will be averaged together or otherwise combined to produce asingle representative value. In some instances, the fastest and slowestreaction times might be dropped before the average or other combinationis calculated. Additionally, it may be useful to save and report thestandard deviation (or other measure of variability) of the recordedscores. The final response score or scores (including, or not, the rawdata curves) will be communicated to the test administrator

By way of one specific example, according to one embodiment a key tomotion response will be to determine an appropriate level of allowablemotion, yet adding sensitivity to the detection of intentional motion.The potential variation in measures of many accelerometers of the sortfound in handheld devices when held perfectly stationary might rangefrom 0.02 g's to 0.025 g's. In addition, since in some embodiments theuser will be holding the device in front of his or her body (e.g., as inFIG. 1), this can lead to added motion beyond resting at a static state.Various threshold and data collection frequency values can be used, forillustrative purposes the current embodiment assigns the followingvalues:

-   -   Threshold: 0.1 g    -   Data Collection Frequency: 1000 hz    -   Reaction Measure: Stimulus to first accelerating value preceding        threshold.

In practice an embodiment might be implemented as follows. The subjectwill be instructed to hold a mobile computing device equipped withbuilt-in triaxis accelerometer and gyroscope with both hands at armslength away from the face. A visual or auditory stimulus is thenpresented on screen via a software application that records the responsetime for the individual to initiate a movement of the device beyond anestablished threshold. A reaction time test includes the movement of thedevice in any axis that breaks a threshold of movement with an analysisof acceleration immediately prior to breaking the threshold to determinewhen intentional motion had been initiated. One embodiment stores theacceleration values as an array to allow for a reverse analysis ofacceleration data points to determine when acceleration started in thedirection of intentional movement, determined by breaking the threshold.

The following method of reaction time testing is a particular example ofhow a test might be performed in practice:

1. The user will be instructed that when a stimulus is presented (e.g.,the screen color will change from white to orange), the device should beshaken or moved.

2. After the user indicates a readiness to participate by pressing a“Begin Test” or similar on-screen button, a one to four secondfore-period or delay (which might be randomly selected) before thestimulus is presented will be used to reduce the likelihood the userwill be able to anticipate the stimulus.3. The stimulus will be presented to the user.4. The accelerometer or other motion sensor will be continuously read.The start time for the reading could be the moment the stimulus ispresented, sometime before that, or a time shortly after itspresentation. In some embodiments values read from the motion sensorbefore the presentation of the stimulus might be used to calculate abaseline movement level. For purposes of this example, if the motionsensor is an accelerometer the values that are read and/or quantitiesnumerically obtained from such readings will be stored in an array A(•),where A(•) contains values that are representative of the motion of thedevice during the recording period. Note that A(•) might actually be amultidimensional array (e.g., A(•, •), A(•, •, •), etc.) where thequantities representative of motion are multidimensional.5. Once the stimulus appears, the user will move the device quickly toexceed the motion threshold (substantial movement).6. The point at which the threshold is broken will denominated as datapoint N, where N corresponds to the sample number within the A(•) arrayat which the measured acceleration is greater than 0.1 g, and where “g”is the acceleration due to gravity.7. The acceleration values leading up to N will have been recorded at1000 hz (1 ms time intervals) and stored in the array A(•) for analysis.8. A query will then be then performed on the acceleration sample pointsprior to N to determine if acceleration was occurring and whenacceleration began (i.e., a search will be conducted for the first“significant movement”). Numerically, this amounts to checking thestored acceleration or other values representative of motion, A(i), i=1,N, in reverse time order:

-   -   Query: Is data point A(N−1)<A(N)?    -   If yes, then is A(N−2)<A(N−1)?, etc.        9. The previous query will continue until is the test is False        (i.e., A(i−1)≥A(i)). At that point, in this example the        algorithm will have determined the earliest moment of        intentional acceleration in response to the stimulus and        reaction time is recorded.        10. Five trials will be repeated to ensure consistency.

Of course, in some instances the data array might be subsampled (toreduce its sample rate), or interpolated (to increase its effectivesample rate). It might also be frequency filtered (e.g., a high pass,low pass, or band pass), subjected to a running average, edited toremove spikes (e.g., via a median filter), etc. Those of ordinary skillin the art will recognize that any number of numerical algorithms mightbe applied to the data to increase its signal-to-noise ratio and make itmore conducive to analysis.

Additionally, it should be noted that tests that include True/False, orGo/No-Go could be administered. This embodiment might provide moreprecise motion recognition of the response which can be superior to theless sensitive touch and voice responses. As an example, in order toperform the True/False function, the user might be instructed to moveleft for false and right for true, then be presented with a question toassess their cognitive ability. The correctness of the response would berecorded, as well as the response time to initiate the responsemovement. A Go/No-Go test could be performed by the same sort of motioncapture physics as previously described, with a No-Go response beingindicated by a one second period of stillness below the 0.005 gthreshold.

In an embodiment the threshold level could also be calibrated per userbased on tremor of that individual. As an example, a familiarizationtrial with a set fore-period of 3 or 4 seconds would allow the user tobetter learn the testing process without actual data collection, whilethe mobile software recorded a baseline tremor level that could be usedto customize the threshold level for that user or as a separateneurological assessment.

Generally speaking, embodiments of the instant invention, operating asthey do on familiar handheld devices such as an iPhone® or a similarhandheld computing device, can eliminate the need for the sort of highcost equipment that is conventionally used in motion based reactionassessment. Embodiments of the instant invention provide a unique andproprietary approach to a combined unit of stimulus presentation (audioand visual), measurement and computation with high quality sensors thatare already built into the device. This approach to motion based captureof reaction time and cognitive function on a portable computing deviceprovides a much more accurate way to measure cognitive function.

Finally, it should be noted and remembered that what is most useful inone embodiment is determining the earliest time at which voluntarymovement of the handheld device is sensed after the stimulus ispresented to the test subject. A method for doing that using motionsensors that are integral to or within a handheld device is taughtherein. Other methods of sensing such motion may readily be devised bythose of ordinary skill in the art.

It should be noted that if reference is made herein to a methodcomprising two or more defined steps, the defined steps can be carriedout in any order or simultaneously (except where context excludes thatpossibility), and the method can also include one or more other stepswhich are carried out before any of the defined steps, between two ofthe defined steps, or after all of the defined steps (except wherecontext excludes that possibility).

It is to be understood that the terms “including”, “comprising”,“consisting” and grammatical variants thereof do not preclude theaddition of one or more components, features, steps, or integers orgroups thereof and that the terms are to be construed as specifyingcomponents, features, steps or integers.

If the specification or claims refer to “an additional” element, thatdoes not preclude there being more than one of the additional element.

It is to be understood that where the claims or specification refer to“a” or “an” element, such reference is not be construed that there isonly one of that element.

It is also to be understood that where the specification states that acomponent, feature, structure, or characteristic “may”, “might”, “can”or “could” be included, that particular component, feature, structure,or characteristic is not required to be included.

Where applicable, although state diagrams, flow diagrams or both may beused to describe embodiments, the invention is not limited to thosediagrams or to the corresponding descriptions. For example, flow neednot move through each illustrated box or state, or in exactly the sameorder as illustrated and described.

Methods of the present invention may be implemented by performing orcompleting manually, automatically, or a combination thereof, selectedsteps or tasks.

The term “method” may refer to manners, means, techniques and proceduresfor accomplishing a given task including, but not limited to, thosemanners, means, techniques and procedures either known to, or readilydeveloped from known manners, means, techniques and procedures bypractitioners of the art to which the invention belongs.

The term “at least” followed by a number is used herein to denote thestart of a range beginning with that number (which may be a rangerhaving an upper limit or no upper limit, depending on the variable beingdefined). For example, “at least 1” means 1 or more than 1. The term “atmost” followed by a number is used herein to denote the end of a rangeending with that number (which may be a range having 1 or 0 as its lowerlimit, or a range having no lower limit, depending upon the variablebeing defined). For example, “at most 4” means 4 or less than 4, and “atmost 40%” means 40% or less than 40%.

When, in this document, a range is given as “(a first number) to (asecond number)” or “(a first number)-(a second number)”, this means arange whose lower limit is the first number and whose upper limit is thesecond number. For example, 25 to 100 should be interpreted to mean arange whose lower limit is 25 and whose upper limit is 100.Additionally, it should be noted that where a range is given, everypossible subrange or interval within that range is also specificallyintended unless the context indicates to the contrary. For example, ifthe specification indicates a range of 25 to 100 such range is alsointended to include subranges such as 26-100, 27-100, etc., 25-99,25-98, etc., as well as any other possible combination of lower andupper values within the stated range, e.g., 33-47, 60-97, 41-45, 28-96,etc. Note that integer range values have been used in this paragraph forpurposes of illustration only and decimal and fractional values (e.g.,46.7-91.3) should also be understood to be intended as possible subrangeendpoints unless specifically excluded.

While this invention is susceptible of embodiment in many differentforms, there is shown in the drawings, and is herein described indetail, some specific embodiments. It should be understood, however,that the present disclosure is to be considered an exemplification ofthe principles of the invention and is not intended to limit it to thespecific embodiments or algorithms so described. Those of ordinary skillin the art will be able to make various changes and furthermodifications, apart from those shown or suggested herein, withoutdeparting from the spirit of the inventive concept, the scope of whichis to be determined by the following claims.

Further, it should be noted that terms of approximation (e.g., “about”,“substantially”, “approximately”, etc.) are to be interpreted accordingto their ordinary and customary meanings as used in the associated artunless indicated otherwise herein. Absent a specific definition withinthis disclosure, and absent ordinary and customary usage in theassociated art, such terms should be interpreted to be plus or minus 10%of the base value.

Additionally, it should be noted that when an operation is said to beperformed in “real time”, that phrase should be understood to mean thatthe operation is performed proximate to the time it is requested asopposed to operations that occur at a much later time. By way ofexample, adjustment of a parameter in real time during a sweep should beunderstood mean the adjust takes place during the sweep and not afterits completion.

Further, it should be noted that when the term “access” is used inconnection with data acquired by a seismic survey that term should beunderstood to mean reading via a computer seismic data that is stored ona volatile or nonvolatile medium. The seismic data acquired during asurvey contains signals that are representative of the configuration ofthe earth proximate to the survey and may or may not have beenpreviously treated with some number of computer algorithms to improveits usability at the time it is accessed. In the event that the term“access” is applied to synthetic or generated seismic data, that usageshould be understood to mean that the data so-accessed has been createdbased on the interaction of computer algorithms that are programmed toutilize the physics of transmission, reflection, diffraction, etc., witha hypothetical model of the earth proximate to some area of interest.

Thus, the present invention is well adapted to carry out the objects andattain the ends and advantages mentioned above as well as those inherenttherein. While the inventive device has been described and illustratedherein by reference to certain preferred embodiments in relation to thedrawings attached thereto, various changes and further modifications,apart from those shown or suggested herein, may be made therein by thoseskilled in the art, without departing from the spirit of the inventiveconcept the scope of which is to be determined by the following claims.

What is claimed is:
 1. A method of measuring a reaction time in asubject, comprising the steps of: a. providing a handheld device to thesubject, said handheld device having a motion sensor and a CPU integralthereto, wherein said CPU is in electronic communication with the motionsensor; b. presenting a stimulus to the subject at a stimulus time aftera selected random period of delay; c. within the handheld device, (c1)using said CPU to continuously read values from the motion sensor atleast from said stimulus time until one or more of said continuouslyread motion values corresponds to an acceleration value greater than orequal to 0.1 g, thereby determining a time of a first substantialmovement; (c2) using said stimulus time, said time of said firstsubstantial movement, and said continuously read motion values from saidmotion sensor to determine a time of a first significant movement thatis earlier than said time of said first substantial movement, therebydetermining the reaction time in the subject, wherein said time of saidfirst significant movement is determined by: (i) searching through saidcontinuously read motion values in reverse order from said substantialmovement time toward said stimulus time to find a first instance where,as between two adjacent continuously read motion values, an earliermeasured one of said two adjacent continuously read motion values isgreater than a later one of said two adjacent continuously read motionvalues, thereby determining a first significant movement, and (ii)determining the reaction time of the subject to be a time of the firstsignificant movement, and (c3) using said CPU to report said reactiontime of the subject.
 2. The method according to claim 1, wherein saidmotion sensor is read by said CPU at intervals of 0.001 seconds or 0.002seconds.
 3. A method measuring a reaction time in a subject, wherein thesubject is provided with a computerized handheld device containingintegral thereto a CPU in electronic communication with anaccelerometer, comprising the steps of: a. using said CPU tocontinuously read baseline values from the accelerometer for apredetermined period of time; b. using any of said read baseline valuesfrom the accelerometer to determine a baseline tremor level; c. using atleast said baseline tremor level to determine a substantial movementlevel greater than said baseline tremor level; and d. after thedetermination of said baseline tremor value and said substantialmovement threshold, (d1) after a selected random period of delay, usingthe handheld device to present a stimulus to the subject at a stimulustime; (d2) using said CPU to continuously read test values from theaccelerometer of at least from said stimulus time until at least one ofsaid test values is greater than said substantial movement threshold,thereby determining a substantial movement time; and (d3) using said CPUto search through said continuously read test values in a reverse timedirection from said substantial movement time toward said stimulus timeto find a first instance where, as between two adjacent continuouslyread test values, an earlier measured one of said two adjacentcontinuously read test values is greater than a later one of said twoadjacent continuously read test values, thereby determining a firstsignificant movement, and (d4) determining the reaction time of thesubject to be a time of the first significant movement, and (e) usingsaid CPU to report said reaction time of the subject.
 4. The methodaccording to claim 3, wherein said baseline values and said test valuesare continuously read from said motion sensor at intervals of 0.001seconds or 0.002 seconds.
 5. The method according to claim 3, whereinsaid substantial movement value is greater than or equal to anacceleration value of 0.1 g.